OptPipe - a pipeline for optimizing metabolic engineering targets

A mixed integer nonlinear programming model for optimizing a gas pipeline transmission linear network

The technical equipment developed and used in both installation and operation processes in refineries, oil and gas pipelines, and gas booster stations has always been expensive. Hence, managers at different organizational levels are keen to find methods to control and reduce these costs. Generally speaking, the operators in a gas booster station choose the operating devices without considering ...

Pipeline Engineering

Cooperative search for optimizing pipeline operations

We present an application of a multi-agent cooperative search approach to the problem of optimizing gas pipeline operations, i.e. finding control parameters for a gas transmission network that result in a low usage of energy to make the required gas deliveries. Our cooperative search approach improves on the pure competition of search agents by having them exchange good solutions from time to t...

Optimizing the Collision Detection Pipeline

Ageneral framework for collision detection is presented. Then, we look at each stage and compare different approaches by extensive benchmarks. The results suggest a way to optimize the performance of the overall framework. A benchmarking procedure for comparing algorithms checking a pair of objects is presented and applied to three different hierarchical algorithms. A new convex algorithm is ev...

Optimizing bioconversion pathways through systems analysis and metabolic engineering.

We demonstrate a general approach for metabolic engineering of biocatalytic systems comprising the uses of a chemostat for strain improvement and radioisotopic tracers for the quantification of pathway fluxes. Flux determination allows the identification of target pathways for modification as validated by subsequent overexpression of the corresponding gene. We demonstrate this method in the ind...